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Cortisol Support
Della Porta et al. (2023). Withania somnifera on cortisol in stressed adults. Nutrients, 15(24):5015.
Evans et al. (2021). AlphaWave® L-theanine on stress in healthy adults. Neurol Ther, 10(2):1061-1078.
Bachour et al. (2025). Ashwagandha on cortisol, stress, and anxiety: systematic review. BJPsych Open.
Akhgarjand et al. (2022). Ashwagandha for anxiety and stress: meta-analysis of RCTs. Phytother Res, 36(11):4115-4124.
Mood Modulation
Yosaee et al. (2022). Zinc in depression: dose-response meta-analysis. Gen Hosp Psychiatry, 74:110-117.
Kell et al. (2017). affron® on mood in healthy adults over 4 weeks. Complement Ther Med, 33:58-64.
Lopresti et al. (2025). Saffron extract (affron®) on mood in low-mood adults. J Nutr, 155(7):2300-2311.
Kell, Graham, et al. “Affron®, a Novel Saffron Extract (Crocus sativus L.), Improves Mood in Healthy Adults over Four Weeks: A Double-Blind, Randomized, Placebo-Controlled Clinical Trial.” Complementary Therapies in Medicine, vol. 33, 2017, pp. 58–64.
Lopresti, Adrian L., Peter D. Drummond, and Julia Smith. “An Examination into the Effects of a Saffron Extract (Affron) on Mood and General Well-Being in Adults Experiencing Low Mood: A Randomized, Double-Blind, Placebo-Controlled Trial.” The Journal of Nutrition, vol. 155, no. 5, 2025, pp. 1420–1429.
Chauhan, S., et al. “Exploring the Potential of Saffron as a Therapeutic Agent in Depression Treatment: A Comparative Review.” Yale Journal of Biology and Medicine, vol. 97, no. 3, 2024, pp. 451–466.
Deep Sleep
Edinger et al. (2021). AASM clinical practice guideline for chronic insomnia. J Clin Sleep Med, 17(2):255-262.
Hieu et al. 2019). Chamomile for anxiety, insomnia, sleep quality: systematic review. Phytother Res, 33(6):1604-1615.
Rondanelli et al. (2024). Lecithin-based Melissa supplementation on emotional distress. J Food Sci Nutr Res, 7:125-130.
Adib-Hajbaghery, M. and Mousavi, S.N. 2017. 'The effects of chamomile extract on sleep quality among elderly people: A clinical trial'. Complementary Therapies in Medicine, vol. 35: 109–114, DOI: 10.1016/j.ctim.2017.09.010.
Hieu, T.H., Dibas, M., Surya Dila, K.A., Sherif, N.A., Hashmi, M.U., Mahmoud, M., Trang, N.T.T., Abdullah, L., Nghia, T.L.B., Y, M.N., Hirayama, K. and Huy, N.T. 2019. 'Therapeutic efficacy and safety of chamomile for state anxiety, generalized anxiety disorder, insomnia, and sleep quality: A systematic review and meta-analysis of randomized trials and quasi-randomized trials'. Phytotherapy Research, vol. 33, no. 6: 1604–1615, DOI: 10.1002/ptr.6349.
Rondanelli, M., Misiano, P., Mansueto, F., Mazzola, G., Barrile, G.C., Gasparri, C. and Perna, S. 2024. 'Three-week daily supplementation of a 200 or 400 mg lecithin-based delivery form of Melissa counterbalances emotional distress symptoms'. Journal of Food Science and Nutrition Research, vol. 7, no. 2: 125–130, DOI: 10.26502/jfsnr.2642-110000159.
Di Pierro, F., Sisti, D., Rocchi, M., Belli, A., Bertuccioli, A., Cazzaniga, M., Palazzi, C.M., Tanda, M.L. and Zerbinati, N. 2024. 'Effects of Melissa officinalis Phytosome on sleep quality: results of a prospective, double-blind, placebo-controlled, and cross-over study'. Nutrients, vol. 16, no. 23: 4199, DOI: 10.3390/nu16234199.